Using solvent evaporation method:
Trehalose and hydroxyethylcellulose composition as matrix material to prepare vancomycin drug formulation. This new prepared delivery system can better maintain the stability of vancomycin drugs in long-term storage and heating (2 hours 90 C) conditions. Especially suitable for severe skin burns or concentrated local treatment.
Choosing hydroxyethyl cellulose, a biocompatible, hydrophilic, expandable, amorphous polymer that, when in contact with an aqueous medium, causes the matrix expansion to form hydrophilic, such as a gel-like viscous dispersion, and gradually becomes permeable, allowing quantitative drug diffusion.The dissolution analysis of the drug system concluded that a single dose of vancomycin could maintain the therapeutic requirement for up to 48 hours.The basic feature of trehalose material is that it is a hydrophilic biocompatible sugar material, which can better prevent the degradation of biological materials from producing , so the combination of the two materials is conducive to give full play to their synergistic effect.
Among them, HEC is the polymer with the most hydrophilic properties and the greatest solubility. Unlike other cellulosic materials, the drug-loaded HEC matrix skeleton shows synchronization of the diffusion and dissolution fronts. With the potential to easily zero-grade release. Further studies also showed that the solubility of drugs. And the molecular weight of the polymer can greatly affect the release kinetics. Choosing medium molecular weight HEC and more soluble drugs can obtain the comparative linear release performance , and the tablet manufacturing can also use the traditional large-scale device process.