Application of hydroxypropyl methylcellulose(HPMC)

The high viscosity level as the suspension liquid preparation, good suspension effect, easy to disperse, no sticky wall, flocculation particles delicate, its common amount of 05%~15 suspension liquid preparation is commonly used in clinical practice, embarrass the heterogeneous dispersion system of soluble solid drugs dispersed in the liquid dispersion medium.The stability of this system determines the quality of the suspended liquid preparation.HPMC body solution can reduce the solid-liquid interface tension, reduce the surface free energy of solid particles, and stabilize the heterogeneous dispersion system.These were prepared with HPMC,

Calamine lotion, loose solid particles, fine and uniform texture, vibration can redisperse the settlement as before.Compared with methyl cellulose, hydroxypropyl methyl cellulose has a more clear solution formation characteristics, only a very small number of undispersed fibers are present, so HPMC is also commonly used in ophthalmic preparations.

The high viscosity level of this product is used to prepare the hydrophilic gel skeleton sustained release tablet, which has the effect of delaying drug release, and its use concentration is 10%~80%.Low viscosity level is used as a pore agent for sustained or controlled release preparation, the initial dose required for the therapeutic effect of such tablets can be quickly reached, and then play sustained or controlled release effect, effective blood concentration is maintained in the body.Hydroxypropyl methylcellulose is hydrated in water to form a gel layer.

The mechanism of drug release from the skeleton sheet is mainly the diffusion of the gel layer and the dissolution of the gel layer.Carvedilol slow-release tablets were prepared using HPMC as the slow-release material.At present, hydroxypropyl methyl cellulose has also been widely used in the slow-release skeleton tablets of traditional Chinese medicine, mostly with its active ingredients, effective parts and unilateral preparations.

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