Application of hydroxypropylmethylcellulose in pharmaceutical preparation(HPMC)

Pharmaceutical excipients are not only the material basis of the formation of API preparations, but also closely related to the difficulty of the preparation process, drug quality, stability, safety, release speed, mode of action, clinical efficacy and the development of new dosage forms and new drug routes.The emergence of new pharmaceutical excipients often promotes the improvement and the development of new dosage forms.

Pharmaceutical excipients hydroxypropyl cellulose (HPC) is a non-ionic cellulose ether obtained from the reaction of alkaline cellulose and propylene oxide at high temperature and high pressure.According to the content of its substituted hydroxypropoxy, it is divided into low substituted hydroxypropyl cellulose (LS-HPC or L-HPC), or (7.0%~16.0%) and high substituted hydroxypropyl cellulose (H-HPC: USP / NF in HPCUSP / NF not exceeding 805%; TP in 534%~77.5%).L-HPC and H-HPC are both white or white-like powder, odorless, tasteless, non-toxic and safe, with good antimicrobial properties.L-HPC in water swelling into colloidal solution in water, insoluble in ethanol, acetone or ether, with adhesive, film, emulsification and other properties, mainly used as a disintegration agent and adhesive: and H-HPC at room temperature soluble water and a variety of organic solvents, with good thermoplasticity, pear knot and film formation, the film hard, good gloss, full elasticity, is mainly used as film material and coating material.

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